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Penvir

Penvir is a guanine analogue used to treat herpes virus infections. It is most commonly used to treat herpes zoster (shingles). Penvir is a prodrug of penciclovir with higher oral bioavailability.

Other names for this medication:
Famciclovir, Famicimac, Famtrex, Microvir, Penvir, Virovir

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Also known as: Famciclovir

Description

Penvir (famciclovir) is an antiviral drug. It slows the growth and spread of the herpes virus so that the body can fight off the infection. Famciclovir will not cure herpes, but it can lessen the symptoms of the infections.

Penvir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles.

Penvir is sometimes used in people with human immunodeficiency virus (HIV) who develop herpes outbreaks around the mouth, genitals, or anal area.

Penvir may not be effective in treating your first episode of genital herpes, but may help prevent future episodes. Famciclovir also may not be effective in Black or African-American people with genital herpes, and may not be effective in any person with shingles (herpes zoster) affecting the eyes.

Penvir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles.

There is no cure for herpes and famciclovir will not prevent you from developing symptoms in the future.

Dosage

Usual Adult Dose for Herpes Simplex -- Mucocutaneous/Immunocompetent Host:

Genital herpes: Initial episode: 250 mg orally 3 times a day for 7 to 10 days has been recommended by the US Centers for Disease Control and Prevention (CDC) Recurrent episodes: 1000 mg orally twice a day for 1 day; alternatively, 125 mg orally twice a day for 5 days has been recommended by the CDC Famciclovir should be started at the first sign or symptom of a recurrent episode (such as tingling, burning, itching, pain, or lesion). The efficacy has not been established if started more than 6 hours after onset of symptoms or lesions.

Usual Adult Dose for Herpes Simplex -- Mucocutaneous/Immunocompromised Host:

Recurrent episodes of orolabial or genital herpes in HIV-infected patients: 500 mg orally twice a day for 7 days (5 to 10 days recommended by the CDC) Famciclovir should be started at the first sign or symptom of a recurrent episode (such as tingling, burning, itching, pain, or lesion). The efficacy has not been established if started more than 48 hours after onset of symptoms or lesions.

Usual Adult Dose for Herpes Simplex -- Suppression:

Chronic suppression of recurrent genital herpes: Immunocompetent patients: 250 mg orally twice a day HIV-infected patients: 500 mg orally twice a day has been recommended by the CDC Therapy should be continued as clinically appropriate, although the safety and efficacy of famciclovir therapy beyond 1 year have not been established.

Usual Adult Dose for Herpes Zoster:

500 mg orally every 8 hours for 7 days Famciclovir is most effective if started within 48 hours of onset of rash. The efficacy has not been established if started more than 72 hours after onset of rash.

Usual Adult Dose for Herpes Simplex Labialis:

Recurrent herpes labialis: 1500 mg orally as a single dose Famciclovir is most effective if started at the earliest sign or symptom of a cold sore (such as tingling, burning, itching, pain, or lesion).

Detailed Penvir dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Penvir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Penvir while you are pregnant or have nurseling. Penvir can pass in breast milk and harm your baby. Do not use Penvir if you are allergic to Penvir components. Do not take probenecid (Benemid). Be careful with Penvir if you have history of galactose intolerance, glucose-galactose malabsorption, kidney disease, severe lactase deficiency. Avoid dehydrating. It is forbidden to take Penvir if you are under 18. Do not stop taking it suddenly.

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Bromberg predicts between political climate for hospital industry. Data of 100 consecutive trauma patients were collected prospectively (2005 cohort) and compared with 100 consecutive trauma patients seen in our previous trauma resuscitation setting (2003 cohort). The antitumor activity of CY and its modification were assessed by growth delay of leg tumors and the reduction in the number of lung metastases. However, new technologies are emerging that allow, among others, immunochemical detection of acetylcholinesterase inhibited by nerve agents. Previous cases of RDD involving the CNS were generally seen in adults. Purification and properties of a keratan sulfate hydrolyzing enzyme, an endo-beta-galactosidase. Qualitative and quantitative changes in epicuticular hydrocarbon synthesis/release were observed during the first gonadotrophic cycle of Calliphora vomitoria.

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